The chronic form of mobic histoplasmosis has a long progressive course. It is characterized by moderate fever, cough with sputum, radiological changes (caverns, fibrosis, multiple calcifications in the lung tissue). Histoplasmosis is often combined with sarcoidosis, tuberculosis, leukemia, reticulosis.
With the development of acute disseminated histoplasmosis against the background of fever and severe general intoxication, multiplee secondary foci of fungal infection in various organs. Damage to the skin and mucous membranes can be manifested by various rashes (maculopapular, hemorrhagic, furuncle-like rash, erythema), ulcerative stomatitis and pharyngitis, subcutaneous tissue abscesses, ulcers of the external genital organs, anus fissures. Among other organ manifestations of disseminated histoplasmosis, lymphadenopathy, meningoencephalitis, retinitis, choroiditis, pericarditis, infective endocarditis, ulcerative colitis, hepatosplenomegaly, mesadenitis, peritonitis can occur. The course of chronic disseminated histoplasmosis is more blurred and sluggish, but inevitably leading to buy mobic online organ lesions.
The course of histoplasmosis has its own characteristics in young children and HIV-infected - in these cases, the disease develops as a disseminated process. Children have a pronounced hepatolienal syndrome, generalized lymphadenopathy, damage to the lungs, skin and intestines. HIV-infected persons suffer from histoplasmosis in about 0.5% of cases, i.e. less often than candidiasis or aspergillosis. The clinical and radiological picture is characterized by lymphadenopathy, high fever, significant hepatosplenomegaly, cough, and pulmonary infiltrates. Mortality from histoplasmosis in this category of patients reaches 80%.
X-ray of the lungs in the acute stage of pulmonary histoplasmosis reveals large and medium focal infiltrates. In the future, at the site of meloxicam, foci of fibrosis and calcification are formed. If acute pulmonary histoplasmosis is suspected, SARS, bacterial pneumonia, atypical pneumonia, psittacosis, Q fever, mycoplasmosis, and tuberculosis are excluded. Chronic histoplasmosis of the lungs requires differentiation from pulmonary forms of deep mycoses (nocardiosis, aspergillosis, coccidioidomycosis, blastomycosis), lymphogranulomatosis. Disseminated forms of mycosis should be distinguished from sepsis and miliary tuberculosis.
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Treatment, prognosis and prevention of histoplasmosis. People with asymptomatic or acute localized histoplasmosis usually do not receive antifungal treatment. In these cases, they are limited to symptomatic therapy and restorative measures. With a long course or severe forms of histoplasmosis, the appointment of antimycotic drugs - itraconazole, ketoconazole, amphotericin B, meglumine sodium succinate is indicated. Along with the systemic use of antimycotics, it is advisable to carry out medicinal inhalations. Additionally, vitamins, antihistamines, good nutrition are recommended. With the development of complications of histoplasmosis, surgical treatment may be required (pericardial puncture, removal of lymph nodes, lung resection, prosthetic heart valves, etc.).
Acute pulmonary histoplasmosis often occurs in an asymptomatic form and usually ends favorably for the patient. Long-term effects of chronic histoplasmosis can be pulmonary fibrosis, arthritis, erythema nodosum, uveitis, encephalopathy, convulsions, heart failure. Disseminated forms pose the greatest threat to order meloxicam online, the elderly, and patients with HIV infection. Nonspecific prevention of histoplasmosis should include soil disinfection, reduction of air dust content, use of respirators during earthworks.